Therapies for various skin conditions utilize medications with isotretinoin, an agent recognized for its unique dermato-protective properties. This substance proves effective against seborrhea, acne, and other skin diseases. It is advisable to use Accutane, a popular isotretinoin-containing drug, under a physician's guidance. User reviews indicate its effectiveness against skin inflammation.
Accutane, a potent retinoid, is a derivative of vitamin A. Isotretinoin, also known as retinoic acid, is the active ingredient and appears as a yellowish powder. This substance has the capability to neutralize rapidly dividing cancer cells, which initially found use in cancer treatments.
Scientists later found another medicinal application of this powdered substance. It can lower sebum production by inhibiting excessive cell epithelium growth in the excretory ducts. This discovery has facilitated the current use of Accutane in the treatment of severe acne. Medicines with this active substance can be used both topically and orally, with the most suitable selection being made by a dermatologist after patient examination.
How does the medicine work?
Accutane is advocated for the effective treatment of acne outbreaks and various skin conditions. The therapeutic impact of this medicine addresses all factors triggering these ailments, primarily by reducing sebum production and cleansing the pores.
The systemic retinoid counteracts the growth of pathological microorganisms, Propionibacterium acnes, which are responsible for acne and pimples. The medicine is also credited with mitigating inflammation and normalizing the skin's pH level. Accutane is commonly used in dermatology and cosmetology as its active ingredient targets, not just disease symptoms but also the root cause of inflammation.
Indications for appointment
Accutane should only be used with a prior prescription from a doctor, given its specific indications. The drug, available as tablets, is prescribed for various conditions, including:
- rosacea (including severe forms),
- all forms of acne,
- nodular cystic acne,
- different types of dermatitis,
- and congenital ichthyosis.
Most of these conditions stem from overactive sebaceous glands disrupting the skin's normal balance.
Exceeding the recommended dosage of isotretinoin can lead to side effects. Most commonly affecting the immune system, patients may experience rashes, redness, skin peeling on the hands and feet, itching, and nail plate degeneration.
Symptoms also include cheilitis, a lip skin disease. Nervous system issues, such as headaches, fatigue, blurred vision, depression, and psychosis, can arise from Accutane use. The medication can also trigger bronchospasm in asthmatic patients, and affect the eyes, causing conditions such as keratitis, blepharitis, optic neuritis, conjunctivitis, and eye irritation. Digestive system and musculoskeletal issues can also occur.
Accutane should not be taken during pregnancy or while planning a pregnancy due to its embryotoxic and teratogenic effects, which can cause developmental abnormalities and birth defects. Pregnancy planning should commence 3-4 months after treatment cessation to allow isotretinoin levels to normalize
Other contraindications include lactation, hypersensitivity or intolerance, combining the drug with tetracycline antibiotics, severe liver and kidney impairment, high lipid blood serum levels, malignant tumors, and Vitamin A hypervitaminosis.
How to take
Accutane oral capsules should be consumed with meals, typically starting with a dosage not exceeding 0.1 mg per kg of the patient's weight. The dosage can be increased depending on the condition's severity and the absence of side effects. The average daily dosage should be divided into multiple doses, and treatment generally lasts 16-24 weeks, with at least two months between treatment courses.
Important issues to remember
It is paramount to remember that Accutane is a powerful medication, and its usage should be strictly under the supervision of a healthcare provider. Being a retinoid, it's known to have significant effects on the body, so careful adherence to the prescribed dosage is crucial to prevent unwanted side effects.
Possible effects range from skin reactions and vision impairment to psychological impacts and musculoskeletal issues. Also, Accutane is known to react negatively with certain other medications, like tetracycline antibiotics, and conditions such as severe liver and kidney impairments. Therefore, full disclosure of your medical history and current medications to your doctor is crucial.
Another critical aspect is the drug's potential risk during pregnancy. Accutane has proven embryotoxic and teratogenic effects, meaning it can cause birth defects and developmental abnormalities. As such, it is strictly contraindicated during pregnancy and even when planning a pregnancy.
Women of childbearing age taking Accutane should use reliable contraception methods and only consider planning a pregnancy 3-4 months post-therapy to allow the body to eliminate isotretinoin completely.
During this period, regular pregnancy tests are advised to ensure the safety of both the mother and the potential fetus. Furthermore, Accutane use is also contraindicated during lactation due to potential harm to the nursing infant.